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A multi-omics framework for decoding disease mechanisms: insights from Methylmalonic aciduria

The results showed that an infusion of carnitine, while it boosted blood carnitine, failed to raise muscle stores over a 5-hour period

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Moreover, high-fat diet-induced mtDNA damage correlates with increased oxidative stress in skeletal muscle and liver, which is associated with the induction of markers of endoplasmic reticulum stress, protein degradation and apoptosis (Yuzefovych et al., 2013)