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Mechanism of Action: In patients taking MAO inhibitors, dietary tyramine is readily absorbed into the systemic circulation due to inhibition of MAO-A present in the epithelial lining of the GI tract (Figure 1)

Liposomal formulations, precursor compounds (NAC), or intravenous delivery may achieve better systemic bioavailability when therapeutic intent requires higher intracellular glutathione levels

Whether youre flying across the country, driving for hours, or bouncing between weekend events, your body pays the price

10.1523/JNEUROSCI.5507-05.2006 60 SchekmanR.OrciL

To this end, we performed immunofluorescence analyses on control (WT), carrier (SORD +/- #1 and SORD +/- #2), and patient (SORD -/- #1, SORD -/- #2 and SORD -/- #3) -derived fibroblasts using an antibody against the outer mitochondrial membrane protein TOM20