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Copper plays a role in multiple aspects of HIF-1 regulation, including the stabilization of HIF-1, formation of transcriptional complexes and binding to hypoxia-responsive element (HRE) sequences of target genes (50)

In our study, ABT 263 (or UBX0101) was first tested because of its reported capacity in clearing senescent cells

Clin Pharmacol Ther, 2014, 96(6): 672683

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