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Furthermore, the concomitant downregulation in -ketoglutarate levels observed in the serum of PD patients suggests a derangement of tricarboxylic acid cycle, which was already reported in other investigations 28,30,31,32

Statins, known for their anti-inflammatory and immunomodulatory functions, have improved right ventricular remodeling in patients with idiopathic PH, hereditary PH, and connective tissue disease-associated PH (Kao, 2005)

Apply a gentle pressure with the fi ngertips, slightly fi rmer than with the serum

To remove the strong acid and base, the samples were diluted with 10 mL of a methanol:water (1:1) solution and concentrated to a final volume of 1 mL using an Amicon 3 kDa MWCO ultra centrifugal filter (Millipore, catalog no

doi: 10.1080/08923973.2023.2196600 139