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These findings indicate that hepatic toxicity associated with anabolicandrogenic steroid use can be severe and, in some cases, life-threatening ( The metabolic consequences of hepatic androgen exposure extend beyond the liver itself

Hypoxia is particularly closely related to the RT efficacy and is the major reason for the ineffectiveness of RT, as oxygen concentration directly influences the generation of cytotoxic free radicals of radiation 32,33

Nat Protoc 2013

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