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Supported by the substantial weight-loss efficacy of the GLP-1MK-801 conjugate and the potentiated hypothalamic changes in transcripts and proteins related to NMDA receptor-linked neuroplasticity, the alteration in MK-801 biodistribution governed by GLP-1-mediated targeting may effectively bypass the delivery of MK-801 to vagal afferent target neurons in the nucleus of the solitary tract

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Additional ser-7, mod-1 , and lgc-50 -expressing neurons that affect aversion from crp remain to be identified

Davisson MT, Beamer WG, Ganschow RE, Vogler CA, Gwynn B, Lyford KA, Maltais LM, Wawrzyniak CJ (April 1989)

2000 Mar-Apr;94(2):99-104