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For example, increased NAD+/NADH ratios promote oxidative metabolism and gluconeogenesis, while decreased ratios favor reductive biosynthesis and lipid synthesis

Stenman LK, Lehtinen MJ, Meland N, Christensen JE, Yeung N, Saarinen MT, et al

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Warnings and Precautions 5.1 Myelosuppression and Increased Risk of Myelosuppression without Vitamin Supplementation ALIMTA can cause severe myelosuppression resulting in a requirement for transfusions and which may lead to neutropenic infection