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Furthermore, MFN2 upregulation in CD8 T cells increases the efficacy of immunotherapy by elevating mitochondria-ER contact, which has been confirmed in anti-tumor therapy ( At the onset of RA, a large number of inflammatory factors such as TNF-, IL-6, IL-17, and IL-1 accumulate in the joints, causing inflammatory storms (Figure 3)

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The ineffective defence mechanism cannot neutralize ROS overproduction in thyroid cancer cells, leading to OxS (122)

Zinc supplementation alleviates the progression of diabetic nephropathy by inhibiting the overexpression of oxidative-stress-mediated molecular markers in streptozotocin-induced experimental rats