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As a dual GLP-1 and GIP receptor agonist, Tirzepatide affects multiple pathways simultaneously: It slows gastric emptying, enhances insulin secretion in a glucose-dependent manner, suppresses glucagon secretion, and powerfully suppresses appetite

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Lammers KM, Lu R, Brownley J et al (2008) Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3