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In Control cells, nutlin-3 treatment down-regulated numerous genes involved in nucleotide metabolism, including DTYMK , CTPS1 , RRM1 , and RRM2 (Fig 3B)

Melatonin Melatonin is an amphiphilic molecule that has been identified as a potent antioxidant therapeutic agent in neurodegenerative diseases (Polimeni et al., 2014) associated with mitochondrial dysfunction (Table 1)

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Typical use concentrations for this ingredient are usually quite low (under 5% in leave-on skincare)

All participants received 600 mg ALA orally per day for 4 weeks and were instructed not to receive any drug that relieves neuropathic pain