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Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK

Accumulation of cellular debris: Photoreceptor outer segments constantly shed and renewed with RPE phagocytosing old segments

In conclusion, while Zahra et al.s clinical trials reported low tolerance to ketogenic diet among patients, findings from preclinical models demonstrate that a 4:1 ketogenic diet can improve response to radiation therapy without increasing toxicity

Meanwhile, ferroptosisan iron-dependent programmed cell death (PCD) first reported by Dixon et al.has emerged as a key player in depression, with studies documenting its presence in neurons and glia and showing that suppressing it alleviates depressive-like behaviors (Dang et al., 2022

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