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It has been demonstrated in numerous in vivo and in vitro investigations that nicotine reduces the levels of IL-1B, IL-2, IL-8, IL-10, and TNF- in colorectal mucosa and blood mononuclear cells [50]

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[17] Known pollinators of Nicotiana rustica include: Augochlorella aurata , Lasioglossum perpunctatum , Bombus impatiens , Lasioglossum tegulare , Augochlora pura , Lasioglossum michiganense , Lasioglossum versans , Bombus vagans , Halictus ligatus , Lasioglossum oblongum , Halictus rubicundus , Megachile frigida , and Sphecodes heraclei