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In hepatic cells, phosphorylated HSP27 promotes autophagy and lipid clearance, suggesting its therapeutic potential in MASLD and non-alcoholic steatohepatitis (NASH), now referred to as metabolic dysfunction-associated steatohepatitis (MASH)

Mirzaei, Application of quercetin in the treatment of gastrointestinal cancers

This suggests that glutamate metabolism is also compartmentalized in osteoclasts with glutamine providing mitochondrial glutamate for mitochondrial transaminases like GOT2