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Where the maximum activity was observed in group 6, groups 4 and 5 indicated significantly lower and invariably similar values during all periods of investigation (i.e., days 130)

It also upregulates the expression of the gastrointestinal barrier proteins ZO-1 and occludin in MPTP-treated mice, improves intestinal barrier function and gastrointestinal dysfunction, and consequently exerts a neuroprotective effect indirectly via the gut-brain axis ( Another study demonstrated that administration of neohesperidin, the primary active component of citrus fruits (25 and 50 mg/kg, administered for 24 days), significantly alleviated MPTP-induced damage to dopaminergic neurons in the substantia nigra-striatal pathway of PD mice, increased levels of striatal dopamine (DA) and its metabolite DOPAC, and improved motor dysfunction

Li Y, Soendergaard C, Bergenheim FH, Aronoff DM, Milne G, Riis LB, et al

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