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Other genes, although with ARE motifs, present CpG islands in their proximal promoters such as GCLC and GCLM, which are characterized by significant association of active histone codes such as H3K4Me1-3, H3K9Ac, H3K27Ac, and H3K79Me2, suggesting a regulatory role of CpG islands in chromatin modifications

Schimmer AD, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M , Schober WD, Nefzi A, Houghten R, Brandwein J, Minden MD, Schuh A, Wells RA, Messner H, Reed JC, Carter BZ