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doi: 10.1152/ajpendo.00069.2023 45

Pemvidutide also resulted in significant reductions in atherosclerotic sphingolipids such as ceramides and sphingomyelins

To avoid this pitfall, we here use PAR2-mutant mice (PAR2-G37I and PAR2-R38E) that retain activation-independent signaling receptor platforms involving PAR2, while abolishing cleavage sensitivity to specific proteases (21, 22, 30, 31)