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Additionally, castration considerably decreased the expression of important antioxidant enzymes (AOEs) (GPx1, thioredoxin, SOD2, and peroxiredoxin 5) and markedly increased the expression of ROS-generating NAD(P)H oxidases

This leads to both the direct nitration and inactivation of the TCR as well as nitration and inhibition of the chemokines CCL2 and CCL5, leading to decreased T cell accumulation within tumors (8486)

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Heres something about glutathione it acts like a shield against oxidative stress, made internally by various systems