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Within the clinical trial setting, retatrutide has been associated with a range of adverse effects, the majority of which are gastrointestinal in nature

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| | 5-Amino-1MQ Monotherapy | None | 50100mg daily | Daily oral or subcutaneous | NNMT inhibition preserves NAD+, activates AMPK and mitochondrial fat oxidation | 812 weeks | Promising preclinical data

Caspase-Glo reagent was added to the wells according to the manufacturers instructions and luminescent signal was measured on a SpectraMax M3 microplate reader (Molecular Devices)