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Upon binding to GHRHR, CJC-1295 without DAC triggers a sophisticated intracellular signaling cascade that begins with conformational changes in the receptor structure, leading to activation of stimulatory G-proteins (Gs) and subsequent stimulation of adenylyl cyclase activity

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By contrast, ATP7A and ATP7B act as copper efflux transporters, regulating the extrusion and subcellular sequestration of excess copper and platinum drugs (250)

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