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The activity of HIF-1 is regulated by oxygen levels, where normoxia promotes HIF-1 degradation and dysfunction while hypoxia ensures its binding to hypoxia response elements, augmenting the transcription of target genes [175]

Jia R, Hou Y, Zhang L et al (2024) Effects of berberine on lipid metabolism, antioxidant status, and immune response in liver of tilapia (Oreochromis niloticus) under a high-fat diet feeding

An interesting approach could be to study changes in gut microbiota composition before and after following an adapted physical activity training program and possible implications in patients with BD, aiding to understand the effects derived from this intervention

59 Other Treatment Considerations Vestibular rehabilitation

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