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Although the cancer risk and other adverse health outcomes associated with vaping CBD are not well established, continued monitoring and research are needed

Nature 499 , 341345 (2013)

However, this change did not reach statistical significance ( p = 0.2640

If you are lean and must use the thigh, always pinch the skin, use a 45-degree angle, and consider a shorter needle (3/8 inch instead of 1/2 inch) to reduce intramuscular injection risk