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Rights and permissions About this article Cite this article Yong, H.Y.F., Yong, V.W

10.1016/j.bbamcr.2012.07.016 Biochim

Proteins 62, 144151

Notably, (1S,3R)-RSL3 (RSL3), a significant inducer of ferroptosis, directly inhibits the activity of GPX4, leading to a reduction in cellular antioxidant capacity, an elevation in lipid ROS and ultimately triggering ferroptosis [40]