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Description

B: biology 114, 3843 (2012)

robust manufacturing includes inprocess controls, multistep purification (e.g., preparative HPLC), and final analytical release testing

After gross total resection (GTR) of the tumor in general, adjuvant radiotherapy [2 Gray (Gy)/day, 5 days/week, 6 weeks plus concurrent daily temozolomide (TMZ, 75 mg/m 2 )], and six cycles of adjuvant TMZ (150200 mg/m 2 , for the first 5 days/28 days per cycle) were administered (Stupp et al