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A 2025 cell line study replicated the telomere-lengthening finding and proposed that epithalon may also activate ALT (Alternative Lengthening of Telomeres) pathways in addition to direct telomerase upregulation

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These pathways include BCL-XL, the cell cycle inhibitor p21, the ephrins EFNB1 and EFNB3, serpin PAI1, the oxygen sensor HIF-1 and phosphatidylinositol 3-kinase-delta (PI3K)

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The oral formulation's convenience advantage over injectable semaglutide would be even more pronounced in pediatric populations, potentially making orforglipron the preferred first-line pharmacological option for adolescent obesity if efficacy and safety data support its use