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Abstract Glyoxalase pathway, comprising glyoxalase I (GLY I) and glyoxalase II (GLY II) enzymes, is the major pathway for detoxification of methylglyoxal (MG) into D-lactate involving reduced glutathione (GSH)

Several studies examining changes in plant polyphenolic content under oxidative stress support this hypothesis, showing that elicitor-induced increases in PAL activity are often accompanied by upregulated polyphenol oxidase activity, ultimately resulting in no net change in polyphenol levels (Cantos et al., 2002

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Glutathione acts as a specialized guard for the mitochondria, cleaning up the metabolic byproducts of energy production

doi: 10.1016/j.ejca.2008.12.027 179 LuYPLouYRYenPNewmarkHLMirochnitchenkoOIInouyeMet al