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* Correspondence: Sichong Ren, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These observations suggest that the cellular consequences of ferritin modulation may vary significantly depending on the tumor type and its cellular origin

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We focused on ferroptosis-related processes including ROS accumulation, lipid peroxidation, iron overload, and GSH depletion, aiming to provide mechanistic insights into the redox-modulating and therapeutic potential of rubidium in glioblastoma