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10.2353/ajpath.2008.070583 Am

Mayo Clinic

Similar concerns apply to phosphodiesterase-5 inhibitors (medications like sildenafil) and L-arginine supplements that also influence nitric oxide signaling

In particular, mature neurons and progenitor cells in the adult rat hippocampus express GIP receptors, and treatment with GIP is able to promote neuronal cell proliferation [39]

Despite some showing nootropic efficacy in animal models or in subjects with cognitive dysfunction (often as a result of dietary deficiencies), these were similarly found to be without effect