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The 5 subunit incorporates into 4 2 receptors as a non-ligand-binding auxiliary subunit, forming ( 4 2 ) 2 5 complexes that exhibit enhanced calcium permeability compared to classical 4 2 receptors and demonstrate resistance to agonist-induced desensitization ( 5 -knockout mice exhibit attenuated responsiveness to nicotine (Morel et al., 2014

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1996 Jan;109(1):194-200

SAC mediates the effect of Keap1/Nrf2/GPX4 signaling pathway on H 2 O 2 -stimulated IEC-6 cells Oxidative stress, by increasing ROS levels, depleting GSH, and inhibiting GPX4 activity, promotes ferroptosis