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Animal studies show that the upregulation of Nrf-2 increases the proliferation of Tregs [319] and amplifies their immunosuppressive and cytotoxic functions [320]

Chest (2018) 154(3):66477

2), DOX administration significantly impaired behavioral activity, evidenced by substantial reductions in exploration time for both familiar and novel objects, with decreases of 47.59-fold and 15.08-fold, respectively, as well as reductions in the number of entries to familiar and novel objects by 4.29-fold and 8.37-fold, respectively, relative to the control group

Lentivirus (LVS), another CRISPR-Cas9 vector, has larger cloning efficiency (8KB) than the AVV vector, allowing sgRNA and Cas9 to be cloned into a single LV vector

Holden et al., 2004