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As well as being activated by other oncogenic signalling pathways, such as in those tumours driven by loss of Phosphatase and tensin homolog (PTEN) or aberrant WNT signalling, 32,33 macropinocytosis can also be induced by the metabolic microenvironment of the tumour, as shown by macropinocytosis of albumin-associated free fatty acids by colorectal cancer cells through G protein-coupled receptor 120 (GPR120)

doi: 10.1507/endocrj.EJ18-0487 65 MaoZGHeDSZhouJYaoBXiaoWWChenCHet al

An HIF-1-specific prolyl-hydroxylase (PHD) hydroxylases proline-564 and/or 402 residues of HIF-1, signaling its ubiquitination and degradation by the proteasome

Dale, A

PubMed evidence trail Research sources used to frame this page For Best Bpc-157 Providers 2027, FormBlends checks the page topic against primary trials, systematic reviews, guidelines, and current PubMed-indexed literature where available