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Although yet unproven in large cross-section populations, some case-control studies have shown that the active treatment of obesity (by Statins) and/or diabetes (by Metformin) may be beneficial for HCC reduction with odds ratio of 0.74 (95% confidence interval (CI): 0.640.87) and 0.38 (95% CI: 0.240.59), respectively [27, 28]

The open nature and high-throughput potential of CFE systems makes them ideal for probing and engineering these interactions

Abstract In the past few years, the gut microbiome has been shown to play an important role in various disorders including in particular cardiovascular diseases

doi: 10.1152/ajpcell.00402.2011

The predominance of cross-sectional designs precludes causal inference and fails to capture temporal dynamics in microbiome composition (Eskandar, 2025)