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Elevated standards

Innervation from splanchnic afferent extends throughout the entire gastrointestinal tract [4]

This action is likely related to SINs ability to enhance IB protein expression, effectively inhibiting NF-B signaling and regulating micro-glial inflammation (4, 95, 96)

While its exact cause remains unknown, factors like genetics, environmental triggers, and abnormalities in blood vessels and immune responses may contribute to the symptoms