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Mutations in the Parkin gene are a major cause of early-onset autosomal-recessive familial PD and isolated juvenile-onset PD [93]

In addition, the derivatives of various plant metabolites can target the GSH/GPX4 pathway and induce ferroptosis

Similarly, to enhance the efficacy of chain-breaking antioxidants, new derivatives with reduced toxicity and improved effectiveness, such as novel synthetic variants, various conjugates, or nanoformulations, specifically targeted to active sites of oxidative stress and particular ROS need to be developed

Messenger, Jeffrey, et al

Given the more direct drug delivery route, intranasally delivered drugs have the potential to be more potent, work more quickly, be better targeted, produce less side effects and be more effective overall