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Arch Biochem Biophys 702:108698 Supinski GS, Schroder EA, Callahan LA (2020) Mitochondria and critical illness

The total enzyme-dependent leaf activity that can be measured in standard assay conditions is around 0.20.5 mol.mg 1 total protein.min 1 , which is typically about twice the total leaf GR activity but somewhat lower than extractable APX (e.g., Sen Gupta et al., A protein purified from spinach by classical biochemical procedures, considered to be a cytosolic DHAR, had K M values of 2.5 mM and 70 M for GSH and DHA, respectively (Hossain and Asada, K M values to these preparations, although the organellar forms in Arabidopsis have a significantly lower affinity for GSH (Table 2)

Cell 144 , 940954 (2011)

The good news is there are no [known] contraindications unless you are allergic to some of the components to taking collagen supplementation and few side effects, says Manning

As you may guess, if something is only recommended in products that you rinse off (cleansers and shampoos), then its probably not the best ingredient for the skin