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Using Primes suite of biochemical and targeted sequencing assays, initial studies detected no off-target editing in human hepatocytes

A deep understanding of the chemical classification of these compounds not only aids in elucidating their pharmacological mechanisms but also provides a theoretical basis for predicting their pharmacokinetic behaviors (e.g., membrane permeability, metabolic stability) and potential clinical translation barriers

Essential branched-chain amino acids (BCAAs) such as isoleucine, leucine and valine, are key both for protein synthesis and increased energy demand [70], so metastases must obtain them from circulation or surrounding tissues

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Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1