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The first phase, Clear, targets active acne using topical isotretinoin to normalize cell turnover and prevent pore occlusion, combined with topical clindamycin to reduce acne-causing bacteria and inflammation

Proteins, including tight junction proteins such as the claudins and occludins control paracellular permeability, defined as the conductance of water and small solutes through the spaces between adjacent epithelial cells [33, 34]

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