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No conflicts of interest were disclosed by the other authors

Moreover, plasminogen activator inhibitor-1 (PAI-1) is a characteristic mediator of SASP and is increased in the sputum and lungs of COPD patients (To et al., 2013)

Continued proof of concepts with other biological analytes such as antibodies and antibody conjugates using this system is necessary

With steroids known to degrade tissues with potential catastrophic effects, it may not make sense to consider them as a first-line therapy to reduce systemic or local inflammation, the present standard in conventional medical thought