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Nat Methods 6:875881

There was a doseresponse association between the daily dose of metformin and a greater risk of neuropathy [49], which could suggest that low vitamin B12 concentrations are a direct cause of neuropathy in those patients

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Related: Vitamin B: Top 6 Benefits of B Vitamins & How to Get More in Your Diet Precautions/When to See Doctor Supplementing with vitamin B12 may not be right for everyone and can even be contraindicated in some cases due to the potential vitamin B12 side effects