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10.1016/j.devcel.2012.03.013 19 BoroM.SinghV.BalajiK

Potential users should be aware that while preclinical safety appears excellent, the absence of extensive human clinical trials means unknown risks may exist

Additionally, they also determined that the expression of protein kinase CPG16 increased, pointing to its importance in suppressing insulin gene expression in pancreatic beta cells under cytotoxicity (164)

These inconsistent results also translate to human studies where obesity and steatosis correlated with increased hepatotoxicity after an APAP overdose in some studies [181] and no correlation of toxicity with obesity was observed in other studies [182]

Moreover, D-lactate has been shown to be metabolized more readily than initially thought, as confirmed by studies on the half-life of D-lactate in plasma and its excretion in urine after infusion or oral administration 110,111