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These include approved prescription weight-loss medications based on synthetic peptides that mimic natural hormones, such as semaglutide and tirzepatide, found in weight loss drugs such as Wegovy and Mounjaro respectively

Although the exact physiological role remains under study, DSIP has been associated with modulation of hypothalamic and pituitary activity in experimental models

Oral formulations have been investigated for their potential effects on the stomach, intestines, and gastrointestinal lining while also being evaluated for broader systemic activity

Experimental work on intestinal anastomosis models and related gastrointestinal injury systems has evaluated endpoints including tissue tensile strength, inflammatory signaling markers, and vascularization within healing intestinal segments

The maintenance of body water balance therefore depends on different physiological processes: the renal regulation, thirst and drinking behavior, but also sweating