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In PAH, DNA methylation mediates CpG site methylation in gene promoters and enhancer regions via DNA methyltransferases (DNMTs), leading to hypermethylation or hypomethylation of immune-metabolic related genes such as EIF2AK4, TCF7, and SOCS3 with concomitant abnormal expression, which enriches functions like T cell differentiation and participates in the pathological process of PAH (Benincasa et al., 2023

These NAD + -dependent deacetylases coordinate AT function and metabolism during aging and obesity (408)

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The idea of a growth hormone fragment that could reduce body fat without the downsides of full GH therapy seemed almost too good to be true

Biomedicines 8 , 284 (2020)