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PT-141 can be an adjunct for those already on other treatments

In a recent in vitro study using human prostate cancer cell lines DU145 and PC3, periprostatic adipose tissue promoted prostate cancer resistance to the chemotherapy drug docetaxel through a mechanism involving paracrine IGF-1 upregulation of the -tubulin isoform of tubulin Beta 2B Class IIb (TUBB2B) gene (31)

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In particular, vaginolysin [198], intermedilysin [198], and high glucose concentrations combined with pore-forming toxins [200] induce necroptosis of erythrocytes at concentrations that dont induce eryptosis