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Only two brands in the ranking are from outside the U.S., the U.K.s Rothmans (brand value down 8 percent to $2.9 billion) and Indonesias Sampoerna (brand value down 12 percent to $2.7 billion).

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In prospective cohort studies, snus use is associated with incident cardiovascular disease and cancer, but results are conflicting and confounding may be difficult to fully adjust for [17, 18]

Compared to conventional cigarettes, similar substances with potential carcinogenic or toxic effects are found in aerosol from electronic cigarettes, but in lower concentrations, whereas emitted reactive oxygen radicals appear comparable [24]

to re-examine menthol in cigarettes. The New York Times