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At the same time, the concept and term of circuitopathies was introduced to describe the disturbances of circuit function and brain-network involved in the pathophysiology of several movement disorders and other neurological diseases (Lozano et al

Also, they found a significant improvement in CRP, erythrocyte sedimentation rate (ESR), procalcitonine, D-dimer, and serum ferritin levels during the duration of the intervention with melatonin [272]

Response: We appreciate and acknowledge these comments related to the implementation of the transfer of care modifiers proposal

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