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Peacock BN, Gherezghiher TB, Hilario JD, Kellermann GH

J Clin Endocrinol Metab 105:dgaa267

Because of the association between mutations in UBE3C gene with patients suffering from severe NDD and ASD, we hypothesized that the UBE3C E3 ligase has fundamental roles in the developing brain

Medical supervision allows for: Dose adjustments based on response Monitoring of biomarkers over time Early identification of imbalances or side effects Integration with nutrition, sleep, and training strategies This long-term view supports sustainability rather than short-term gains