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For our purposes, superoxide in the matrix has two main fates ( Figures 13 and 14 )

This effect of MT-1G is achieved by blocking the GSH depletion-mediated lipid peroxidation to inhibit ferroptosis in HCC cells, independent of iron ion content

Different mechanisms have been proposed in different cellular, organ, and animal models, including transcellular and paracellular routes

According to research studies, lipoate, a conjugate base of ALA takes part in several oxidative metabolic processes where it is reduced to dihydrolipoate under physiological conditions