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2026;290:123388 Reis L

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RG7112 selectively cleared senescent intervertebral disc cells, reduced senescence-associated secretory phenotype (SASP) factors, and improved disc matrix homeostasis in human disc tissue

However, neither BAL fluid nor intracellular GSH, GSSG, and GSH:GSSG correlated with BAL eosinophils or any other inflammatory cell, suggesting eosinophilia plays a lesser role in contributing to higher extracellular/BAL fluid GSSG than epithelial cells do (Supplemental Tables 3 and 4)