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Methylene blue vasoplegic syndrome treatment addresses the severe blood pressure drop post-cardiac surgery by inhibiting nitric oxide synthase and guanylate cyclase, stabilizing blood pressure

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In the next step (step 2), the resolving Cys forms an intramolecular disulfide bond with the C P by releasing H 2 O

Adult ICU patients meeting Sepsis-3 criteria and diagnosed with delirium during ICU stay were included