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Compartmentalization and flux of antioxidants in cancer cells While the subcellular compartmentalization and transport of ROS and antioxidants in healthy cells are relatively well-characterized, this is not the case in tumors (Hecht et al

The ubiquitin ligase STIP1 homology and U-box containing protein 1 (STUB1) ubiquitinates lysine 63 (K63), which then binds and degrades HIF1A in the lysosome, in conjunction with CMA proteins (111,112)

Future research should focus on personalized antioxidant therapy guided by biomarker profiling to optimize clinical outcomes

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