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Comorbidities present in pillar pain patients included hypertension (48%), hypothyroidism (30%), rheumatoid arthritis (26%), diabetes mellitus (22%), fibromyalgia (9%), and vitamin deficiencies (9%), with no cases of chronic kidney disease in this sample

This decision followed the German Federal Institute for Drugs and Medical Devices (BfArM) Long COVID expert group, which developed a symptom-specific evidence package rather than relying on a single class-wide claim

Marcu, et al

Immunological: Anti-inflammatory mechanism and cytokine suppression studies

To build upon existing technology, the Direct to Phase II (DP2) approach is essential to maintain momentum for operational energy modernization and avoid re-creating existing technology through a Phase I SBIR